We are either creations of space-time; creators of space-time; or just visitors journeying through space-time.
If we are creations of space-time, as science assumes, we live and die within space-time. For how could we exist outside of space-time if we are created and supported by it?
If we are the creators of space-time, then we seemingly cannot be hurt by anything that seems to happen in space-time. Damage done or things achieved my be seen to be illusions when we are no longer are focused on space-time. This is the view of Vedanta.
If we are primarily non-physical beings journeying through a realm we did not create (in this case space-time), though may in some way be co-creating, we cannot presumably be destroyed by it either as our essence must exist separately from the physical form it temporarily inhabits.